An interview with John Gurdon.
نویسنده
چکیده
John Gurdon is a Distinguished Group Leader in the Wellcome Trust/Cancer Research UK Gurdon Institute and Professor Emeritus in the Department of Zoology at the University of Cambridge. In 2012, he was awarded the Nobel Prize in Physiology or Medicine jointly with Shinya Yamanaka for work on the reprogramming of mature cells to pluripotency, and his lab continues to investigate the molecular mechanisms of nuclear reprogramming by oocytes and eggs. We met John in his Cambridge office to discuss his career and hear his thoughts on the past, present and future of reprogramming.
منابع مشابه
Sir John Gurdon: Godfather of cloning
S ir John Gurdon's famous frog cloning experiments of the 1960s and '70s answered a question that had been hanging over cell biologists since before the turn of the century: are the cells of an adult organism genetically identical to the fertilized egg from which they are derived? Briggs and King in the early '50s suggested that cells' genetic material is irreversibly altered as they begin to d...
متن کامل"The Developmental Capacity of Nuclei Taken from Intestinal Epithelium Cells of Feeding Tadpoles" (1962), by John B. Gurdon
In 1962 researcher John Bertrand Gurdon at the University of Oxford [3] in Oxford, England conducted a series of experiments on the developmental capacity of nuclei taken from intestinal epithelium [4] cells of feeding tadpoles. In the experiments, Gurdon conducted nuclear transplantation, or cloning [5], of differentiated cells, or cells that have already specialized to become one cell type or...
متن کامل"Developmental Capacity of Nuclei Transplanted from Keratinized Skin Cells of Adult Frogs" (1975), by John Gurdon, Ronald Laskey, and O. Raymond Reeves
In 1975 John Gurdon [4], Ronald Laskey [5], and O. Raymond Reeves [6] published ?Developmental Capacity of Nuclei Transplanted from Keratinized Skin Cells of Adult Frogs,? in the Journal of Embryology and Experimental Morphology. Their article was the capstone of a series of experiments performed by Gurdon during his time at Oxford and Cambridge, using the frog [7] species Xenopus laevis [8]. G...
متن کاملSir John Gurdon: father of nuclear reprogramming.
Sir John Gurdon founded the field of nuclear reprogramming. His work set the stage for the ever burgeoning area of stem cell biology and regenerative medicine. Here I provide personal reflections on times I shared with John Gurdon and professional reflections of the impact of his ground-breaking research on my own development as a scientist and on the field in general. His paradigm-shifting exp...
متن کاملThe egg and the nucleus: a battle for supremacy (Nobel Lecture).
Sir John Gurdon and Professor Shinya Yamanaka were the recipients of the 2012 Nobel Prize for Physiology or Medicine. This Spotlight article is a commentary on the early nuclear transplant work in Xenopus, which was very important for the Nobel award in 2012, and the influence of this work on the reprogramming field.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Development
دوره 144 9 شماره
صفحات -
تاریخ انتشار 2017